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Carprofen Tablets (20mg/50mg)
Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of inflammation and to provide analgesia. There is good absorption from the gastrointestinal tract following oral administration. There is a high degree of protein binding and a small volume of distribution that is mostly to extracellular sites. Carprofen is a weak acid, so it readily penetrates into inflamed tissue. Elimination is usually following metabolism by hepatic enzymes, and the less active metabolites are eliminated via a combination of fecal and urinary excretion. Urinary excretion of the unchanged drug is minimal, and relies on glomerular filtration and tubular excretion. There is also a degree of hepatic excretion and evidence of enterohepatic recycling